Prematurity epigenome and proteome as a clue for
prediction of prematurity complications
NEOMICS – project number 196065
prediction of prematurity complications
NEOMICS – project number 196065
News
The Neomics project has been completed
On April 30, 2017 The Neomics project has been completed. During the 3 years and 7 months, the complex research studies which focused on the prematurity complications have been performed. The studies were carried out by two approaches.The Norwegian partner used an experimental mice model of BPD and ROP, based on the exposure to different oxygen concentrations. In Cracow and Warsaw Neonatal Centers a prospective recruitment of 164 newborns delivered ≤ 30 weeks of gestational age was performed. Among these newborns there were 47 extremely immature babies, delivered ≤ 26 weeks of gestational age which are characterized by increased risk of development of BPD and/or ROP complications.
As a comparison a control group of healthy 30 term newborns were also registered. In both study arms –experimental and human, a genome wide expression and methylation profile were analyzed as well as the proteome assessment depending on gestational age and the exposure to hyperoxia.
Currently the crude results of expression, methylation and proteome are subjected to extensive analyses by extremely powerful bio statistical tests and in the future will be published in the peer review scientific journals.
- Presentation
Contact:
Jagiellonian University Medical CollegeFaculty of Medicine
Polish-American Children’s Hospital
Chair of Pediatrics
30-663 Kraków, Poland
Wielicka 265 Street
phone (4812) 658 02 56
fax (4812) 658 44 46
e-mail: klinchdz@cm-uj.krakow.pl
Principal Investigator:
Jacek Józef Pietrzyk MD, Ph.D.
Professor of Pediatrics
Project is co-funded from Norway Grants in the Polish-Norwegian Research Programme operated by the National Centre for Research and Development