Prematurity epigenome and proteome as a clue for
prediction of prematurity complications
NEOMICS – project number 196065
prediction of prematurity complications
NEOMICS – project number 196065
Partners
University of Oslo
Department of Pediatric Research, Oslo University Hospital Rikshospitalet, Norwayhttp://ous-research.no/pediatricresearch/
The Pediatric Research Institute (PFI) was established as a joint university and hospital institute at the Rikshospitalet in Oslo in 1959. In the first years, research focused on hematology; however, soon a whole range of research topics was established, including metabolic diseases, pediatric cancer, adverse effects of bilirubin, and basic research on the effect of peptides on diseases. During the last 20 years, the research focus was primarily on the effect of hypoxia-reoxygenation injury and oxidative stress, especially during the neonatal period. For this purpose, a number of animal models and cell culture models were established at the PFI. The department has extensive laboratory facilities filled with modern equipment, the staff of the department is very experienced and focused on research. The ongoing research topics at the department are: hypoxia and oxidative stress, pediatric liver kidney alimentary nutrition and transplantation, infections and immunology, type 1 diabetes risk and also pediatric cancer. PFI collaborates extensively with a number of national and international research groups (i.e from France, Italy, Spain, Danmark, Sweden and also Poland). PFI is run by a famous professor Ola Didrik Saugstad, whose research on the field on the hypoxia and reoxygenation of the newborn led to change in Newborn Resuscitation Guidelines in 2010.
Warsaw Medical University
Prof. dr hab. n. med. Maria Katarzyna Borszewska -KornackaNeonatal and Intensive Care Department Medical University of Warsaw
Neonatal and Intensive Care Department of Medical University of Warsaw is tertiary clinical center, which provides also teaching and scientific activity . Departments has 68 neonatal beds including 12 intensive care ,10 intermediate care , 10 continuous care Our intensive care wards is a biggest in Mazovia region which admit inborn and outborn newborns. Every year about 3500 newborns are hospitalized including about 300 who need intensive care The number of newborn below 1500g is more than 100 newborns .Department is equipped with very modern ventilators for conventional, HFO ventilation as well as many different CPAP devices. We provide therapeutic hypothermia not only for newborns born in Mazovia ( Warsaw) region but also from North and Easter part of Poland. We have a modern monitoring system, diagnostic equipment as: ultrasound, ECHO,NIRS, aEEG. We are a teaching center for medical students , nursing as well and physicians specializing in the field of neonatology, pediatrics and obstetrics. We are organizer of the biggest number (9) of the courses regarding neonatal ultrasound and ECHO Conducted research concerning surfactant treatment, probiotics, neonatal infection jaundice lactation and tissue Doppler.
The Department of Neonatology and Neonatal Intensive Care Medical University of Warsaw is a level 3-university referral center, combining both research and clinical services.
The department consists of 68 beds, divided between 3 wards:
- 12-bed Neonatal Intensive Care Unit [largest in the Mazovia region]
- 20-bed Special Care Unit
- 36 bed Postnatal Ward
About 3,500 newborns are hospitalized within our unit, with approximately 300 requiring intensive care. We take care of more than 100 babies weighing < 1500g annually. The center is equipped with the latest neonatal ventilators for conventional as well as volume and oscillatory ventilation, together with modern diagnostic testing such as ECHO, NIRS, and AEEG. We also provide therapeutic hypothermia for newborns with symptoms of hypoxia, not only from Mazovia but also from other regions of northern and eastern Poland.
Our unit delivers undergraduate education for medical students, together with postgraduate teaching for nurses and neonatal, pediatric and obstetric residents. We organize the largest number (9 per year) of courses on neonatal ultrasound and echocardiography.
Our research is mainly focused on surfactant, probiotics, and osteopenia of prematurity, neonatal infections, breast milk, neonatal jaundice, as well as assessment of myocardial function in tissue Doppler options.
Omicron
About the projectThe overall objective of the project is to up-grade, stimulate, unlock, develop and extend the research potential of the Faculty of Medicine at the Jagiellonian University Medical College (JUMC). The project is running since January 1st 2012.
The specific objectives are:
- to up-grade and extend the laboratory equipment and research performance at JUMC Faculty of Medicine allowing for most advanced genomic and proteomic research;
- to attract, develop and retain at the JUMC Faculty of Medicine the best research professionals of Polish origin and foreigners;
- to develop the research skills of the future leaders in the thematic domains concerned;
- to establish and expand networks across Europe to support high quality research, exchange of know-how and experience and ensure technology and knowledge transfer so that leading edge research can thrive at JUMC Faculty of Medicine;
- to increase the visibility of excellence of the JUMC Faculty of Medicine and ensure the setting-up of long-lasting strategic partnerships with leading centres in the respective priority fields;
- to increase the participation of beneficiaries in scientific fields covered by the EC FP7 and in future HORIZON 2020.
The OMICRON Project is run by 5 Departments at the Jagiellonian University Medical College:
- Department of Metabolic Diseases
- Department of Pharmacology
- Department of Transplantation
- Department of Internal and Agricultural Medicine
- Third Department of General Surgery
OMICRON’s Proteomics
Proteomics laboratory of OMICRON centre at Jagiellonian University Medical College will be equipped with high-throughput 2-D electrophoresis system, enabling simultaneous analysis of twelve large-size polyacrylamide gels, both in isocratic and gradient mode. Protein identification and shotgun-based proteomics techniques will be conducted on sensitive, reproducible and versatile mass spectrometer coupled with ultra-performance liquid chromatography system (U-HPLC).
Proteomics, standing at the cross-road between genes, proteins and disease, can play an important role in molecular medicine, drug discovery and diagnostics. Identifying unique profiles of protein expression, or new biomarkers associated with specific diseases are some of the most challenging but also most promising targets in modern clinical proteomics.
The main Project Coordinator is the Representative of the Rector of the Jagiellonian University for Research and Development at the Medical College - prof. Maciej Małecki, MD, PhD (Department of Metabolic Diseases).
Contact:
Jagiellonian University Medical CollegeFaculty of Medicine
Polish-American Children’s Hospital
Chair of Pediatrics
30-663 Kraków, Poland
Wielicka 265 Street
phone (4812) 658 02 56
fax (4812) 658 44 46
e-mail: klinchdz@cm-uj.krakow.pl
Principal Investigator:
Jacek Józef Pietrzyk MD, Ph.D.
Professor of Pediatrics
Project is co-funded from Norway Grants in the Polish-Norwegian Research Programme operated by the National Centre for Research and Development